Article
A mutation in the human apolipoprotein A-I gene. Dominant effect on the level and characteristics of plasma high density lipoproteins.
The Journal of biological chemistry - 25 Jul 1991
Deeb S S, Cheung M C, Peng R L, Wolf A C, Stern R, Albers J J, Knopp R H
Abstract excerpt
Epidemiologic and genetic data suggest an inverse relationship between plasma high density lipoprotein (HDL) cholesterol and the incidence of premature coronary artery disease. Some of the defects leading to low levels of HDL may be a consequence of mutations in the genes coding for HDL apolipopr...
Topics
- Amino Acid Sequence
- Apolipoprotein A-I
- Apolipoprotein A-II
- Apolipoproteins
- Apolipoproteins A
- Apolipoproteins D
- Base Sequence
- Blotting, Southern
- Chromosome Deletion
- Genes, Dominant
- Humans
- Lipid Metabolism, Inborn Errors
- Lipoproteins, HDL
- Molecular Sequence Data
- Mutation
- Oligonucleotides
- Pedigree
- Polymerase Chain Reaction