Article
The genome-wide patterns of variation expose significant substructure in a founder population.
American journal of human genetics - 1 Dec 2008
Jakkula Eveliina, Rehnström Karola, Varilo Teppo, Pietiläinen Olli P H, Paunio Tiina, Pedersen Nancy L, deFaire Ulf, Järvelin Marjo-Riitta, Saharinen Juha, Freimer Nelson, Ripatti Samuli, Purcell Shaun, Collins Andrew, Daly Mark J, Palotie Aarno, Peltonen Leena
Abstract excerpt
Although high-density SNP genotyping platforms generate a momentum for detailed genome-wide association (GWA) studies, an offshoot is a new insight into population genetics. Here, we present an example in one of the best-known founder populations by scrutinizing ten distinct Finnish early- and late-settlement subpopulations. By determining genetic distances, homozygosity, and patterns of linkage disequilibrium,...
Topics
Join the communities discussing this publication.