Article
Association analyses between type 2 diabetes genes and obesity traits in pigs.
Obesity (Silver Spring, Md.) - 1 Feb 2009
Du Zhi-Qiang, Fan Bin, Zhao Xia, Amoako Randy, Rothschild Max F
Abstract excerpt
To investigate candidate genes involved in human type 2 diabetes (T2D) for obesity-related phenotypes in pigs. Statistical association analyses of genes with fat deposition were realized in a pig reference family constructed by two breeds, Berkshire and Yorkshire. Extensive sequencing was then attempted to discover the causative polymorphism. Genes implied in human T2D development, TCF7L2, WFS1, FTO, SLC30A8, and...
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