Article
Comparative Analyses of QTLs Influencing Obesity and Metabolic Phenotypes in Pigs and Humans.
PloS one - 1 Jan 2015
Pant Sameer D, Karlskov-Mortensen Peter, Jacobsen Mette J, Cirera Susanna, Kogelman Lisette J A, Bruun Camilla S, Mark Thomas, Jørgensen Claus B, Grarup Niels, Appel Emil V R, Galjatovic Ehm A A, Hansen Torben, Pedersen Oluf, Guerin Maryse, Huby Thierry, Lesnik Philipppe, Meuwissen Theo H E, Kadarmideen Haja N, Fredholm Merete
Abstract excerpt
The pig is a well-known animal model used to investigate genetic and mechanistic aspects of human disease biology. They are particularly useful in the context of obesity and metabolic diseases because other widely used models (e.g. mice) do not completely recapitulate key pathophysiological features associated with these diseases in humans. Therefore, we established a F2 pig resource population (n = 564) designed...
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