Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Successful Low-Risk Hematopoietic Cell Therapy in a Mouse Model of Type 1 Gaucher Disease

5 Dec 2008

Abstract excerpt

Hematopoietic stem cell-based gene therapy offers the possibility of permanent correction for genetic disorders of the hematopoietic system. However, optimization of present protocols is required before gene therapy can be safely applied as general treatment of genetic diseases. In this study we have used a mouse model of type 1 Gaucher disease (GD) to demonstrate the feasibility of a low-risk conditioning...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Lysosomal Storage Disorders Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19056909
DOI: 10.1634/stemcells.2008-0844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Successful Low-Risk Hematopoietic Cell Therapy in a Mouse Model of Type 1 Gaucher DiseasePMID 19056909Read ↗

Effective cell and gene therapy in a murine model of Gaucher disease.Semantic proximity Read ↗

Mobilization-based engraftment of haematopoietic stem cells: a new perspective for chemotherapy-free gene therapy and transplantationSemantic proximity Read ↗

[Molecular diagnosis and gene therapy for Gaucher disease].Semantic proximity Read ↗

Gaucher disease gene <i>GBA</i> functions in immune regulationSemantic proximity Read ↗

Comparable human reconstitution following Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice.Semantic proximity Read ↗

Radiation-sensitive severe combined immunodeficiency: The arguments for and against conditioning before hematopoietic cell transplantation—what to do?Semantic proximity Read ↗

Hematopoietic Tumors in a Mouse Model of X-linked Chronic Granulomatous Disease after Lentiviral Vector-Mediated Gene TherapySemantic proximity Read ↗

The Role of Glycosphingolipids in Autoimmune Manifestations and Myeloma in Gaucher DiseaseSemantic proximity Read ↗

Non-Clinical Efficacy and Safety Studies on G1XCGD, a Lentiviral Vector for Ex Vivo Gene Therapy of X-Linked Chronic Granulomatous DiseaseSemantic proximity Read ↗

Methylguanine methyltransferase–mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal modelSemantic proximity Read ↗

Demonstration of Feasibility of In Vivo Gene Therapy for Gaucher Disease Using a Chemically Induced Mouse ModelSemantic proximity Read ↗

Impact of Abbreviated Filgrastim Schedule on Survival and Hematopoietic Recovery after Irradiation in Four Mouse Strains with Different RadiosensitivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.