Article
Identification of the proton channel to the active site type 2 Cu center of nitrite reductase: structural and enzymatic properties of the His254Phe and Asn90Ser mutants.
Biochemistry - 23 Dec 2008
Hough Michael A, Eady Robert R, Hasnain S Samar
Abstract excerpt
Proton and electron delivery to the catalytic site and their associated pathways are crucial elements in understanding the mechanisms of redox enzymes. Two distinct proton channels have previously been identified in copper nitrite reductases based on high- to atomic-resolution crystal structures. These were assigned as the "primary" and "high-pH" proton channels and link the catalytic type 2 Cu center to the...
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