Article
Insights into redox partner interactions and substrate binding in nitrite reductase from Alcaligenes xylosoxidans: crystal structures of the Trp138His and His313Gln mutants.
Biochemistry - 28 Dec 2004
Barrett Mark L, Harris Roger L, Antonyuk Svetlana, Hough Michael A, Ellis Mark J, Sawers Gary, Eady Robert R, Hasnain S Samar
Abstract excerpt
Dissimilatory nitrite reductase catalyses the reduction of nitrite to nitric oxide within the key biological process of denitrification. We present biochemical and structural results on two key mutants, one postulated to be important for the interaction with the partner protein and the other for substrate entry. Trp138, adjacent to one of the type-1 Cu ligands, is one of the residues surrounding a small...
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