Article
Raltegravir susceptibility and fitness progression of HIV type-1 integrase in patients on long-term antiretroviral therapy.
Antiviral therapy - 1 Jan 2008
Buzón Maria José, Marfil Silvia, Puertas Maria C, Garcia Elisabet, Clotet Bonaventura, Ruiz Lidia, Blanco Julìa, Martinez-Picado Javier, Cabrera Cecilia
Abstract excerpt
BACKGROUND: HIV type-1 (HIV-1) protease (PR), reverse transcriptase (RT) and integrase (IN) share the same precursor polyprotein and there is much evidence to suggest functional interactions between IN and RT. We aimed to elucidate whether long-term highly active antiretroviral therapy (HAART) targeting PR and RT could influence raltegravir susceptibility and the fitness of IN. METHODS: HIV-1 IN sequences from 45...
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