Article
Mutation pattern of human immunodeficiency virus gene.
Journal of molecular evolution - 1 May 1991
Moriyama E N, Ina Y, Ikeo K, Shimizu N, Gojobori T
Abstract excerpt
Human immunodeficiency viruses (HIVs) show extensive genetic variation. This feature is the fundamental cause of pathogenicity of HIVs and thwarts efforts to develop effective vaccines. To understand the mutation mechanism of these viruses, we analysed nucleotide sequences of env and gag genes of the viruses by use of molecular evolutionary methods and estimated the direction and frequency of nucleotide...
Topics
- Base Sequence
- DNA, Viral
- Genes, env
- Genes, gag
- HIV
- Mutation