Article
Prognostic significance of tumor iNOS and COX-2 in stage III malignant cutaneous melanoma.
Cancer immunology, immunotherapy : CII - 1 Jul 2009
Johansson C Christian, Egyházi Suzanne, Masucci Giuseppe, Harlin Helena, Mougiakakos Dimitrios, Poschke Isabel, Nilsson Bo, Garberg Liss, Tuominen Rainer, Linden Diana, Stolt Marianne Frostvik, Hansson Johan, Kiessling Rolf
Abstract excerpt
PURPOSE: New prognostic markers are needed for malignant melanoma. Inducible nitric oxide synthase (iNOS) and cyclooxygenase type 2 (COX-2) have been described to correlate with progression of melanoma. Moreover, activating mutations in BRAF/NRAS oncogenes are often detected in melanoma. The BRAF/NRAS mutation status and expression of COX-2 and iNOS were examined to compare their prognostic value for overall...
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