Article
COX-2 expression positively correlates with PD-L1 expression in human melanoma cells.
Journal of translational medicine - 23 Feb 2017
Botti Gerardo, Fratangelo Federica, Cerrone Margherita, Liguori Giuseppina, Cantile Monica, Anniciello Anna Maria, Scala Stefania, D'Alterio Crescenzo, Trimarco Chiara, Ianaro Angela, Cirino Giuseppe, Caracò Corrado, Colombino Maria, Palmieri Giuseppe, Pepe Stefano, Ascierto Paolo Antonio, Sabbatino Francesco, Scognamiglio Giosuè
Abstract excerpt
BACKGROUND: The resistance to PD-1/PD-L1 inhibitors for the treatment of melanoma have prompted investigators to implement novel clinical trials which combine immunotherapy with different treatment modalities. Moreover is also important to investigate the mechanisms which regulate the dynamic expression of PD-L1 on tumor cells and PD-1 on T cells in order to identify predictive biomarkers of response. COX-2 is...
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