Article
Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies.
Breast cancer research : BCR - 1 Jan 2008
Kelemen Linda E, Couch Fergus J, Ahmed Shahana, Dunning Alison M, Pharoah Paul D P, Easton Douglas F, Fredericksen Zachary S, Vierkant Robert A, Pankratz V Shane, Goode Ellen L, Scott Christopher G, Rider David N, Wang Xianshu, Cerhan James R, Vachon Celine M
Abstract excerpt
INTRODUCTION: The stroma is the supportive framework of biologic tissue in the breast, consisting of various proteins such as the proteoglycans, decorin and lumican. Altered expression of decorin and lumican is associated with breast tumors. We hypothesized that genetic variation in the decorin (DCN) and lumican (LUM) genes may contribute to breast cancer. METHODS: We investigated associations of 14 common...
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