Article
Gene expression variation between distinct areas of breast cancer measured from paraffin-embedded tissue cores.
BMC cancer - 25 Nov 2008
Schobesberger Martina, Baltzer Anna, Oberli Andrea, Kappeler Andreas, Gugger Mathias, Burger Hana, Jaggi Rolf
Abstract excerpt
BACKGROUND: Diagnosis and prognosis in breast cancer are mainly based on histology and immunohistochemistry of formalin-fixed, paraffin-embedded (FFPE) material. Recently, gene expression analysis was shown to elucidate the biological variance between tumors and molecular markers were identified that led to new classification systems that provided better prognostic and predictive parameters. Archived FFPE samples...
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