Article
The effect of angiotensin-converting enzyme genotype on acute mountain sickness and summit success in trekkers attempting the summit of Mt. Kilimanjaro (5,895 m).
European journal of applied physiology - 1 Feb 2009
Kalson Nicholas S, Thompson Julian, Davies Andrew J, Stokes Suzy, Earl Mark D, Whitehead Adam, Tyrrell-Marsh Ian, Frost Hannah, Montgomery Hugh
Abstract excerpt
The I-allele rather than the D-allele of the human angiotensin converting enzyme (ACE) gene has been associated with high-altitude mountaineering success. We investigated whether the I-allele was associated with summit success, and also with AMS development, in altitude-naïve trekkers. Subjects ascended from 1,860 m to the summit over 4 days (n = 34, 'direct-profile') or 5 days (n = 82, 'slower-profile')....
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