Article
Erythrocyte Webb-type glycophorin C variant lacks N-glycosylation due to an asparagine to serine substitution.
American journal of hematology - 1 May 1991
Telen M J, Le Van Kim C, Guizzo M L, Cartron J P, Colin Y
Abstract excerpt
We have analyzed part of the sequence of the human glycophorin C (GPC) gene carried by a Webb blood-group positive donor. Our results indicate that the lack of N-glycosylation of the variant GPC associated with the Webb phenotype is due to a point mutation resulting in an asparagine to serine substitution at amino acid position 8.
Topics
- Amino Acids
- Asparagine
- Blood Group Antigens
- Blotting, Western
- DNA
- Erythrocytes
- Genetic Variation
- Glycophorins
- Glycosylation
- Humans
- Immune Sera
- Mutation