Article
Investigation of genetic variants of alpha-1 acid glycoprotein by ultra-performance liquid chromatography-mass spectrometry.
Analytical and bioanalytical chemistry - 1 Feb 2009
Budai Lívia, Ozohanics Oliver, Ludányi Krisztina, Drahos László, Kremmer Tibor, Krenyacz Judit, Vékey Károly
Abstract excerpt
Genetic variants of human plasma alpha-1 acid glycoprotein (AGP) have been studied in cancer, compared with a group of healthy control. AGP has four genetic variants: AGP F1, F2, and S variants correspond to the ORM1 gene whereas AGP A corresponds to the ORM2 gene. The proportion of ORM1 and ORM2 variants were studied in plasma using a novel UPLC-MS method. Plasma total AGP level was 0.5 +/- 0.2 g L(-1) and the...
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