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Article

Photoaffinity antigens for human gammadelta T cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2008

Sarikonda Ghanashyam, Wang Hong, Puan Kia-Joo, Liu Xiao-hui, Lee Hoi K, Song Yongcheng, Distefano Mark D, Oldfield Eric, Prestwich Glenn D, Morita Craig T

Abstract excerpt

Vgamma2Vdelta2 T cells comprise the major subset of peripheral blood gammadelta T cells in humans and expand during infections by recognizing small nonpeptide prenyl pyrophosphates. These molecules include (E)-4-hydroxy-3-methyl-but-2-enyl-pyrophosphate (HMBPP), a microbial isoprenoid intermediate, and isopentenyl pyrophosphate, an endogenous isoprenoid intermediate. Recognition of these nonpeptide Ags is...

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PMID: 19017963
DOI: 10.4049/jimmunol.181.11.7738
PMCID: PMC2696061

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