Article
Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis.
Clinica chimica acta; international journal of clinical chemistry - 1 Feb 2009
Lee Li-Ching, Chen Chiung-Mei, Chen Fen-Lin, Lin Pei-Ying, Hsiao Ya-Chin, Wang Pin-Rong, Su Ming-Tsan, Hsieh-Li Hsiu-Mei, Hwang Ji-Chuu, Wu Chung-Hsin, Lee Guan-Chiun, Singh Sher, Lin Yenshou, Hsieh Sen-Yung, Lee-Chen Guey-Jen, Lin Jung-Yaw
Abstract excerpt
BACKGROUND: Expansion of the CAG repeat of the TATA-box binding protein (TBP) gene has been identified as the causative mutations in spinocerebellar ataxia 17 (SCA17). TBP is ubiquitously expressed in both central nervous system and peripheral tissues. The underlying molecular changes of SCA17 ar...
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