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Article

Variations within oxygen-regulated gene expression in humans.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Jan 2009

Brooks Jerome T S, Elvidge Gareth P, Glenny Louisa, Gleadle Jonathan M, Liu Chun, Ragoussis Jiannis, Smith Thomas G, Talbot Nick P, Winchester Laura, Maxwell Patrick H, Robbins Peter A

Abstract excerpt

The effects of hypoxia on gene transcription are mainly mediated by a transcription factor complex termed hypoxia-inducible factor (HIF). Genetic manipulation of animals and studies of humans with rare hereditary disease have shown that modifying the HIF pathway affects systems-level physiologica...

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Identifiers

PMID: 19008490
DOI: 10.1152/japplphysiol.90578.2008
PMCID: PMC2636937

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19008490-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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