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Article

Dengue virus regulates type I interferon signalling in a strain-dependent manner in human cell lines

13 Nov 2008

Abstract excerpt

Outbreaks of dengue disease are constant threats to tropical and subtropical populations but range widely in severity, from mild to haemorrhagic fevers, for reasons that are still elusive. We investigated the interferon (IFN) response in infected human cell lines A549 and HepG2, using two strains (NGC and TSV01) of dengue serotype 2 (DEN2) and found that the two viruses exhibited a marked difference in inducing...

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PMID: 19008393
DOI: 10.1099/vir.0.2008/001594-0

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