Article
Unidimensional nonnegative scaling for genome-wide linkage disequilibrium maps.
International journal of bioinformatics research and applications - 1 Jan 2008
Liao Haiyong, Ng Michael, Fung Eric, Sham Pak C
Abstract excerpt
The main aim of this paper is to propose and develop a unidimensional nonnegative scaling model to construct Linkage Disequilibrium (LD) maps. The proposed constrained scaling model can be efficiently solved by transforming it to an unconstrained model. The method is implemented in PC Clusters at Hong Kong Baptist University. The LD maps are constructed for four populations from Hapmap data sets with chromosomes...
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