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Article

FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians.

Diabetologia - 1 Feb 2009

Yajnik C S, Janipalli C S, Bhaskar S, Kulkarni S R, Freathy R M, Prakash S, Mani K R, Weedon M N, Kale S D, Deshpande J, Krishnaveni G V, Veena S R, Fall C H D, McCarthy M I, Frayling T M, Hattersley A T, Chandak G R

Abstract excerpt

AIMS AND HYPOTHESIS: Variants of the FTO (fat mass and obesity associated) gene are associated with obesity and type 2 diabetes in white Europeans, but these associations are not consistent in Asians. A recent study in Asian Indian Sikhs showed an association with type 2 diabetes that did not seem to be mediated through BMI. We studied the association of FTO variants with type 2 diabetes and measures of obesity...

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19005641
DOI: 10.1007/s00125-008-1186-6
PMCID: PMC2658005

Genes

FTO

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Related research

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FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians.PMID 19005641Read ↗

An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference.Semantic proximity Read ↗

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FTO genetic variants and risk of obesity and type 2 diabetes: a meta-analysis of 28,394 Indians.Semantic proximity Read ↗

Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians.Semantic proximity Read ↗

Common variants of FTO and the risk of obesity and type 2 diabetes in Indians.Semantic proximity Read ↗

FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.Semantic proximity Read ↗

Genetic variations in the FTO gene are associated with type 2 diabetes and obesity in south Indians (CURES-79).Semantic proximity Read ↗

Associations of variants in FTO and near MC4R with obesity traits in South Asian Indians.Semantic proximity Read ↗

Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children.Semantic proximity Read ↗

Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population.Semantic proximity Read ↗

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.Semantic proximity Read ↗

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.Semantic proximity Read ↗

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