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Article

Hyperstable miniproteins: additive effects of D- and L-Ala mutations.

Organic & biomolecular chemistry - 7 Dec 2008

Williams D Victoria, Barua Bipasha, Andersen Niels H

Abstract excerpt

The folding enantioselectivity for D-Ala versus L-Ala at one glycine site in the Trp-cage is 16 kJ mol(-1); judicious introductions of alanines of the correct chirality raises the melting temperature of this 20-residue fold to 83 degrees C.

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Source

Identifiers

PMID: 19005584
DOI: 10.1039/b814314e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19005584-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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