Article
Inhibitory effects of coffee on the genotoxicity of carcinogens in mice.
Mutation research - 1 Feb 1991
Abraham S K
Abstract excerpt
The mouse bone marrow micronucleus test was carried out to evaluate the possible inhibitory effects of 3 doses (125, 250 and 500 mg/kg) of standard instant coffee on the in vivo genotoxicity of 7,12-dimethylbenz[a]anthracene (DMBA), benzo[a]pyrene (BP), aflatoxin B1 (AFB1) and urethane (UR). Coffee was orally administered twice, 2 and 20 h before the carcinogens were injected intraperitoneally. From the results...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Aflatoxin B1
- Aflatoxins
- Animals
- Benzo(a)pyrene
- Bone Marrow
- Carcinogens
- Coffee
- Cyclophosphamide
- Dose-Response Relationship, Drug
- Drug Interactions
- Male