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Article

A novel duplication confirms the involvement of 5q23.2 in autosomal dominant leukodystrophy.

Archives of neurology - 1 Nov 2008

Meijer Inge A, Simoes-Lopes Ana A, Laurent Sandra, Katz Tanya, St-Onge Judith, Verlaan Dominique J, Dupré Nicolas, Thibault Manon, Mathurin Johanne, Bouchard Jean-Pierre, Rouleau Guy A

Abstract excerpt

OBJECTIVE: To identify the underlying locus and disease-causing mutation for adult-onset autosomal dominant leukodystrophy (ADLD). DESIGN: Previously, an adult-onset ADLD locus on chromosome 5q23 was mapped between markers D5S1495 and CTT/CCT15. This region contains 13 known and putative candidate genes. A 2-point linkage analysis confirmed linkage of a large multigenerational French Canadian family to chromosome...

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Source

Identifiers

PMID: 19001169
DOI: 10.1001/archneur.65.11.1496

Genes

LMNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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