Article
Hereditary lymphedema: evidence for linkage and genetic heterogeneity.
Human molecular genetics - 1 Dec 1998
Ferrell R E, Levinson K L, Esman J H, Kimak M A, Lawrence E C, Barmada M M, Finegold D N
Abstract excerpt
Hereditary or primary lymphedema is a developmental disorder of the lymphatic system which leads to a disabling and disfiguring swelling of the extremities. Hereditary lymphedema generally shows an autosomal dominant pattern of inheritance with reduced penetrance, variable expression and variable...
Topics
- Chromosomes, Human, Pair 5
- DNA
- DNA Mutational Analysis
- Family
- Family Health
- Female
- Genetic Heterogeneity
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Humans
- Lod Score
- Lymphedema
- Male
- Pedigree
- Point Mutation
- Receptor Protein-Tyrosine Kinases