Article
Diversity of glutathione s-transferase omega 1 (a140d) and 2 (n142d) gene polymorphisms in worldwide populations.
Clinical and experimental pharmacology & physiology - 1 Mar 2009
Takeshita Haruo, Fujihara Junko, Takastuka Hisakazu, Agusa Tetsuro, Yasuda Toshihiro, Kunito Takashi
Abstract excerpt
1. Glutathione S-transferase class omega (GSTO) 1 and 2 are members of the glutathione-S-transferase family, which uses glutathione in the process of the biotransformation of drugs, xenobiotics and oxidative stress. Associations with the age-at-onset of Alzheimer's and Parkinson's diseases have been shown in the genetic polymorphism of GSTO1 and GSTO2. 2. In the present study, the frequencies of GSTO1*A140D and...
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