Article
Absence of somatic SQSTM1 mutations in Paget's disease of bone.
The Journal of clinical endocrinology and metabolism - 1 Feb 2009
Matthews Brya G, Naot Dorit, Bava Usha, Callon Karen E, Pitto Rocco P, McCowan Stuart A, Wattie Diana, Cundy Tim, Cornish Jill, Reid Ian R
Abstract excerpt
BACKGROUND: Paget's disease is a common focal bone disorder that appears to be caused by a combination of genetic and environmental factors. Mutations in the SQSTM1 gene are found in about one third of families with Paget's disease and 8% of sporadic cases. Other potential loci linked to the disease have also been identified, and a number of environmental factors have been suggested to be involved in the disease....
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