Article
NRP/B mutations impair Nrf2-dependent NQO1 induction in human primary brain tumors.
Oncogene - 22 Jan 2009
Seng S, Avraham H K, Birrane G, Jiang S, Li H, Katz G, Bass C E, Zagozdzon R, Avraham S
Abstract excerpt
Brain tumors are associated with genetic alterations of oncogenes and tumor suppressor genes. Accumulation of reactive oxygen species (ROS) in cells leads to oxidative stress-induced damage, resulting in tumorigenesis. Here, we showed that the nuclear matrix protein nuclear restricted protein in brain (NRP/B) was colocalized and interacted with NF-E2-related factor 2 (Nrf2). During oxidative stress response,...
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