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Article

Neuropilin-1 promotes Hedgehog signaling through a novel cytoplasmic motif.

The Journal of biological chemistry - 15 Sept 2017

Pinskey Justine M, Franks Nicole E, McMellen Alexandra N, Giger Roman J, Allen Benjamin L

Abstract excerpt

Hedgehog (HH) signaling critically regulates embryonic and postnatal development as well as adult tissue homeostasis, and its perturbation can lead to developmental disorders, birth defects, and cancers. Neuropilins (NRPs), which have well-defined roles in Semaphorin and VEGF signaling, positively regulate HH pathway function, although their mechanism of action in HH signaling remains unclear. Here, using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28667171
DOI: 10.1074/jbc.M117.783845
PMCID: PMC5602381

Genes

NRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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