The mutation beta 99 Asp-Tyr stabilizes Y--a new, composite quaternary state of human hemoglobin.

doi:10.1002/prot.340100202

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Article

The mutation beta 99 Asp-Tyr stabilizes Y--a new, composite quaternary state of human hemoglobin.

Proteins - 1 Jan 1991

Smith F R, Lattman E E, Carter C W

Abstract excerpt

Carbonmonoxy hemoglobin Ypsilanti (beta 99 Asp-Tyr) exhibits a quaternary form distinctly different from any structures previously observed for human hemoglobins. The relative orientation of alpha beta dimers in the new quaternary form lies well outside the range of values observed for normal unl...

Topics

Allosteric Site
Amino Acid Sequence
Aspartic Acid
Carboxyhemoglobin
Hemoglobins, Abnormal
Humans
Hydrogen Bonding
Ligands
Molecular Sequence Data
Mutation
Protein Conformation
Tyrosine
X-Ray Diffraction

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