Article
p16INK4a expression and absence of activated B-RAF are independent predictors of chemosensitivity in melanoma tumors.
Neoplasia (New York, N.Y.) - 1 Nov 2008
Gallagher Stuart J, Thompson John F, Indsto James, Scurr Lyndee L, Lett Margaret, Gao Bo-Fu, Dunleavey Ruth, Mann Graham J, Kefford Richard F, Rizos Helen
Abstract excerpt
Metastatic cutaneous melanoma is highly resistant to cytotoxic drugs, and this contributes to poor prognosis. In vivo studies on the chemosensitivity of metastatic melanoma are rare and hampered by poor response rates to systemic chemotherapeutics. Patients who undergo isolated limb infusion (ILI) with cytotoxic drugs show high response rates and are, therefore, a good cohort for studying chemosensitivity in...
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