Article
The effect of nitric oxide on vaccinia virus-encoded ribonucleotide reductase.
Nitric oxide : biology and chemistry - 1 Mar 2009
Fujikura Yuzo, Kudlackova Pavla, Vokurka Martin, Krijt Jakub, Melkova Zora
Abstract excerpt
Growth inhibition of the DNA virus vaccinia (VACV) by NO is known to occur at the level of DNA synthesis. This inhibition is partially reversed by addition of deoxyribonucleosides, suggesting that NO or NO-related species inhibit viral ribonucleotide reductase (RR). However, the effect of NO on VACV-encoded RR or other DNA-synthesizing enzymes has not been demonstrated. In order to study the effects of NO on...
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