Article
Oligonucleotide array CGH studies in myeloproliferative neoplasms: comparison with JAK2V617F mutational status and conventional chromosome analysis.
Leukemia research - 1 May 2009
Tefferi Ayalew, Sirhan Shireen, Sun Yi, Lasho Terra, Finke Christy M, Weisberger James, Bale Sherri, Compton John, LeDuc Charles A, Pardanani Animesh, Thorland Erik C, Shevchenko Yuriy, Grodman Marc, Chung Wendy K
Abstract excerpt
Comparative genomic hybridization (CGH), using oligo arrays with either 44,000 or 105,000 oligonucleotides, was performed on granulocyte-derived DNA from 71 patients with BCR-ABL-negative classic myeloproliferative neoplasms (MPNs): 32 primary myelofibrosis (PMF), 26 polycythemia vera (PV) and 13 essential thrombocythemia (ET). Copy number changes (CNCs) were detected in 44%, 35%, and 15% of the cases with PMF,...
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