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Article

Relationship between dyskerin expression and telomerase activity in human breast cancer.

1 Jan 2008

Abstract excerpt

The nucleolar protein dyskerin is involved in the modification of specific uridine residues to pseudouridine on ribosomal and small nuclear RNAs and in the stabilization of the telomerase RNA component (TERC). In this study we investigated for the first time the relationship between dyskerin expression and telomerase activity in a series of 61 primary breast carcinomas. We found that when dyskerin mRNA values...

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Identifiers

PMID: 18936525
DOI: 10.3233/clo-2008-0436

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Relationship between dyskerin expression and telomerase activity in human breast cancer.PMID 18936525Read ↗

Dyskerin expression influences the level of ribosomal RNA pseudo‐uridylation and telomerase RNA component in human breast cancerSemantic proximity Read ↗

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DKC1 Overexpression Induces a More Aggressive Cellular Behavior and Increases Intrinsic Ribosomal Activity in Immortalized Mammary Gland CellsSemantic proximity Read ↗

Dyskerin is required for tumor cell growth through mechanisms that are independent of its role in telomerase and only partially related to its function in precursor rRNA processingSemantic proximity Read ↗

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Dyskeratosis congenita mutations in dyskerin SUMOylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects.Semantic proximity Read ↗

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The C-terminal extension of dyskerin is a dyskeratosis congenita mutational hotspot that modulates interaction with telomerase RNA and subcellular localization.Semantic proximity Read ↗

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