Article
Simple method for analyzing the pattern of DNA polymorphism and its application to SNP data of human.
Genes & genetic systems - 1 Aug 2008
Nawa Nobukazu, Tajima Fumio
Abstract excerpt
In order to analyze the pattern of DNA polymorphism in detail, we have developed a simple method using a new statistic theta(i) which estimates 4Nmu from the number of segregating sites whose allelic nucleotide frequency is i/n among n DNA sequences, where N is the effective population size and mu is the mutation rate per generation per nucleotide site. Under the assumption that mutations are selectively neutral...
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