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Article

Absence of effect of chronic nicotine administration on amyloid beta peptide levels in transgenic mice overexpressing mutated human APP (Sw, Ind).

Neuroscience letters - 26 Dec 2008

Sabbagh Marwan N, Walker Douglas G, Reid Richard T, Stadnick Tiffany, Anand Keshav, Lue Lih-Fen

Abstract excerpt

Studies have indicated that nicotine has disease-modifying and cognitive-enhancing properties in Alzheimer's disease (AD). Nicotine has been proposed to be neuroprotective through anti-amyloid beta (Abeta) effects, anti-excitotoxic effects, and anti-free radical effects. Previously, conflicting data from Abeta plaque developing transgenic mice have shown significant Abeta-lowering effects, or alternatively no...

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Source

Identifiers

PMID: 18926877
DOI: 10.1016/j.neulet.2008.10.004

Genes

APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of effect of chronic nicotine administration on amyloid beta peptide levels in transgenic mice overexpressing mutated human APP (Sw, Ind).PMID 18926877Read ↗

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