Article
Role of polymorphisms in Adamantiades-Behçet's disease.
The Journal of rheumatology - 1 Dec 2008
Kaklamani Virginia G, Sadim Maureen, Koumantaki Yvoni, Kaklamanis Phedon, Pasche Boris
Abstract excerpt
OBJECTIVE: We previously showed that Adamantiades-Behçet's disease (A-BD) is associated with a lower incidence of malignancy compared with the general population. Transforming growth factor-beta (TGF-beta) has been shown to play a role in cartilage regeneration and is increased in patients with A-BD. We also found 2 functional polymorphisms of the TGF-beta pathway, TGFBR1*6A and TGFB1*CC, that are associated with...
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