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Article

The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels.

The Journal of pharmacology and experimental therapeutics - 1 Jan 2009

Godlewski Grzegorz, Offertáler László, Osei-Hyiaman Douglas, Mo Fong Ming, Harvey-White Judith, Liu Jie, Davis Margaret I, Zhang Li, Razdan Raj K, Milman Garry, Pacher Pal, Mukhopadhyay Partha, Lovinger David M, Kunos George

Abstract excerpt

The novel endocannabinoid-like lipid N-arachidonoyl L-serine (ARA-S) causes vasodilation through both endothelium-dependent and -independent mechanisms. We have analyzed the vasorelaxant effect of ARA-S in isolated vascular preparations and its effects on Ca(2+)-activated K(+) currents in human embryonic kidney cells stably transfected with the alpha-subunit of the human, large conductance Ca(+)-activated K(+)...

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Identifiers

PMID: 18923087
DOI: 10.1124/jpet.108.144717
PMCID: PMC2605781

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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