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Article

Resistance to trimethoprim in Haemophilus influenzae.

Infection - 1 Jan 2000

Powell M, Hu Y, Livermore D M

Abstract excerpt

The mechanisms of resistance to trimethoprim in eleven U.K. clinical isolates of Haemophilus influenzae were studied. The levels of dihydrofolate reductase (DHFR) activities in crude extracts from four resistant wild-types were similar to those in susceptible controls. However, activities in extracts from the other seven resistant wild-type isolates, and transformants of two of these, were at least triple those...

Topics

Folic Acid Antagonists
Haemophilus influenzae
Mutation
Species Specificity
Tetrahydrofolate Dehydrogenase
Transformation, Bacterial
Trimethoprim
Trimethoprim Resistance
United Kingdom

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1889872
DOI: 10.1007/BF01643245

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1889872-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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