Article
Effect of cloned inhibitor-resistant TEM beta-lactamases on the susceptibility of Haemophilus influenzae to amoxicillin/clavulanate.
The Journal of antimicrobial chemotherapy - 1 Nov 2007
Tristram Stephen G, Burdach Jonathan G
Abstract excerpt
OBJECTIVES: To determine the effect of cloned inhibitor-resistant TEM beta-lactamases (IRTs) on the susceptibility of Haemophilus influenzae to amoxicillin/clavulanate. METHODS: IRT-2, -4 and -5 genes with various promoters were cloned into control strains of H. influenzae and the amoxicillin/clavulanate MICs were measured using Etests. RESULTS: IRT enzymes were able to raise the amoxicillin/clavulanate MICs to...
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