Article
Disappearance of the protein of a somatic mutation: a possible example of stem cell inactivation.
The American journal of physiology - 1 Sept 1991
Adams J G, Hardy C L, Steinberg M H
Abstract excerpt
The low concentration of the hemoglobin variant, Hb Vicksburg (leucine-beta-75 deleted), and a profound deficit of its mRNA led us to postulate that a beta(+)-thalassemia mutation existed in cis to the coding region mutation, suppressing its synthesis. We examined blood from this patient 6, 8, and 10 yr after our initial studies, using methods of analysis unavailable initially. We found 1) mutations causing...
Topics
- Adolescent
- Aging
- Amino Acid Sequence
- Amino Acids
- Base Sequence
- Cloning, Molecular
- DNA
- Globins
- Hemoglobin A
- Hemoglobins, Abnormal
- Humans
- Leukocytes