Article
[The mutagenicity of a new multicomponent vaccine made from the antigens of Klebsiella pneumoniae, Staphylococcus aureus, Proteus vulgaris and Escherichia coli].
Zhurnal mikrobiologii, epidemiologii i immunobiologii - 1 Jun 1991
Volgareva G M, Tolcheev Iu D, Egorova N B, Mansurova N L, Silin A M, Anpilogova O R
Abstract excerpt
Inactivated bacterial vaccine, containing K. pneumoniae, S. aureus, P. vulgaris and E. coli antigenic complexes were tested for mutagenicity in the test described by Ames et al. and in vivo, in experiments on mice. In Salmonella typhimurium cells, strain TA-98 and TA-100, the preparation (5-75 mg/ml) did not increase the frequency of reversions and histidine-independence either in direct experiments or after...
Topics
- Animals
- Antigens, Bacterial
- Bacterial Vaccines
- Bone Marrow
- Chromosome Aberrations
- Drug Combinations
- Escherichia coli
- Genes, Bacterial
- Klebsiella pneumoniae
- Male