Article
Dynamic regulation of yeast glycolytic oscillations by mitochondrial functions.
Journal of cell science - 1 Jun 1991
Aon M A, Cortassa S, Westerhoff H V, Berden J A, Van Spronsen E, Van Dam K
Abstract excerpt
The control exerted in vivo by mitochondrial functions on the dynamics of glycolysis was investigated in starved yeast cells that were metabolizing glucose semianaerobically. Glycolytic oscillations were triggered after a pulse of glucose by inhibition of mitochondrial respiration with KCN, myxothiazol and antimycin A or in mutants in the bc1 complex (ubiquinol:cytochrome c reductase) that were largely deficient...
Topics
- Adenosine Triphosphate
- Computer Simulation
- Glycolysis
- Mitochondria
- Models, Biological
- Mutation
- NADP
- Oxygen Consumption
- Saccharomyces cerevisiae