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Modulation between aerobic and anaerobic metabolism in the mutant cell line CdtR-Q.

Bollettino della Societa italiana di biologia sperimentale - 1 Jan 2000

Lofrumento D D, Panaro M A, Mitolo V

Abstract excerpt

It has recently been shown that the cell line Don Q obtained by mutagenesis of wild type Chinese hamster lung fibroblasts (Don wt), presents a point mutation in the gene coding for UDP-glucose pyrophosphorylase. The persistent low level of UDP-glucose makes Don Q clone resistant to Clostridium difficile toxin B. Starting from the observation that Don Q cells exhibit many large hydrophobic cytoplasmic inclusions,...

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PMID: 10874983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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