Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family.

doi:10.1001/archneur.64.10.1436

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Article

Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family.

Archives of neurology - 1 Oct 2007

Brouwers Nathalie, Nuytemans Karen, van der Zee Julie, Gijselinck Ilse, Engelborghs Sebastiaan, Theuns Jessie, Kumar-Singh Samir, Pickut Barbara A, Pals Philippe, Dermaut Bart, Bogaerts Veerle, De Pooter Tim, Serneels Sally, Van den Broeck Marleen, Cuijt Ivy, Mattheijssens Maria, Peeters Karin, Sciot Raf, Martin Jean-Jacques, Cras Patrick, Santens Patrick, Vandenberghe Rik, De Deyn Peter P, Cruts Marc, Van Broeckhoven Christine, Sleegers Kristel

Abstract excerpt

BACKGROUND: Progranulin gene (PGRN) haploinsufficiency was recently associated with ubiquitin-positive frontotemporal lobar degeneration linked to chromosome 17q21 (FTLDU-17). OBJECTIVE: To assess whether PGRN genetic variability contributed to other common neurodegenerative brain diseases, such as Alzheimer disease (AD) or Parkinson disease (PD). DESIGN: Mutation analysis of PGRN. SETTING: Memory Clinic of the...

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PMID: 17923627
DOI: 10.1001/archneur.64.10.1436

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