Article
DNA repair of 8-oxo-7,8-dihydroguanine lesions in Porphyromonas gingivalis.
Journal of bacteriology - 1 Dec 2008
Henry Leroy G, Sandberg Lawrence, Zhang Kangling, Fletcher Hansel M
Abstract excerpt
The persistence of Porphyromonas gingivalis in the inflammatory environment of the periodontal pocket requires an ability to overcome oxidative stress. DNA damage is a major consequence of oxidative stress. Unlike the case for other organisms, our previous report suggests a role for a non-base excision repair mechanism for the removal of 8-oxo-7,8-dihydroguanine (8-oxo-G) in P. gingivalis. Because the uvrB gene...
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