Article
The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion.
Molecular biology of the cell - 1 Dec 2008
Kurischko Cornelia, Kuravi Venkata K, Wannissorn Nattha, Nazarov Pavel A, Husain Michelle, Zhang Chao, Shokat Kevan M, McCaffery J Michael, Luca Francis C
Abstract excerpt
Saccharomyces cerevisiae Cbk1 is a LATS/Ndr protein kinase and a downstream component of the regulation of Ace2 and morphogenesis (RAM) signaling network. Cbk1 and the RAM network are required for cellular morphogenesis, cell separation, and maintenance of cell integrity. Here, we examine the phenotypes of conditional cbk1 mutants to determine the essential function of Cbk1. Cbk1 inhibition severely disrupts...
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