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Article

Topology and membrane anchoring of the coronavirus replication complex: not all hydrophobic domains of nsp3 and nsp6 are membrane spanning.

Journal of virology - 1 Dec 2008

Oostra Monique, Hagemeijer Marne C, van Gent Michiel, Bekker Cornelis P J, te Lintelo Eddie G, Rottier Peter J M, de Haan Cornelis A M

Abstract excerpt

Coronaviruses express two very large replicase polyproteins, the 16 autoproteolytic cleavage products of which collectively form the membrane-anchored replication complexes. How these structures are assembled is still largely unknown, but it is likely that the membrane-spanning members of these nonstructural proteins (nsps) are responsible for the induction of the double-membrane vesicles and for anchoring the...

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Identifiers

PMID: 18842706
DOI: 10.1128/JVI.01219-08
PMCID: PMC2593338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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