Article
Membrane rearrangements mediated by coronavirus nonstructural proteins 3 and 4.
Virology - 1 Jun 2014
Hagemeijer Marne C, Monastyrska Iryna, Griffith Janice, van der Sluijs Peter, Voortman Jarno, van Bergen en Henegouwen Paul M, Vonk Annelotte M, Rottier Peter J M, Reggiori Fulvio, de Haan Cornelis A M
Abstract excerpt
Coronaviruses replicate their genomes in association with rearranged cellular membranes. The coronavirus nonstructural integral membrane proteins (nsps) 3, 4 and 6, are key players in the formation of the rearranged membranes. Previously, we demonstrated that nsp3 and nsp4 interact and that their co-expression results in the relocalization of these proteins from the endoplasmic reticulum (ER) into discrete...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.